ABSTRACT
About half of Nigerian population experience at least one episode of malaria per year, resulting in high morbidity and mortality and loss of economic value. Retrospective study of the profile of malarial patients and the antimalarial drugs prescribed at Umaru Musa Yaradua memorial Hospital, Sabon-Wuse, Niger State, Nigeria were undertaken. The Plasmodium species among the malarial patients were also studied. The susceptibility of the predominant species to the prescribed antimalarial drugs was investigated. PCR analysis of the DNA of the resistant Plasmodiuum species isolates against the test antimalarials were studied using Qiagen DNeasy blood and tissue kit method. The retrospective study showed that Artemisinin Combination Therapy (ACT) was the predominantly prescribed drugs while the month of May and October had the highest incidence of malarial infection in the years studied. Plasmodium falciparum (85.7%) was the predominant malaria parasite isolated from malaria patients in Sabon-Wuse, Niger State, Nigeria. Plasmodium malariae accounts for only 14.5% of the malaria parasite observed in the area. Only 5% of the P. falciparum parasites were sensitive in vitro to Chloroquine. PCR analysis of the DNA indicated the presence of Pfcrt-Ra Gene in the study area, which further confirms resistance to Chloroquine. Plasmodium falciparum isolates were observed to be sensitive in vitro to Artesunate-Amodiaquine drug in the study area. The investigation also shows that all the samples analysed had multi antimalarial drug resistant gene Pfcrt/FB (76T). A high percentage (87.5%) of the samples analysed displayed the multidrug resistant gene Pfcrt/FB (76K) at 76 bp. The result of the PCR analysis of the DNA corroborates the observed in vitro susceptibility studies. Thus, there is the need for periodic antimalarial surveillance in order to curb emergence of multi antimalarial drug resistance as observed in Sabon-Wuse.
ABSTRACT
The study was carried out to investigate the influence of clothing consumption pattern of women on the family standard of living...
Abstract
Yoghurt is a smooth, viscous get and nutty flavoured dairy product resulting from the acidification of milk by fermentation. Thi...
BACKGROUND OF THE STUDY
Criminal activities occasioned by cultism are not limited to Bayelsa and Bayels...
ABSTRACT
This study was carried out on the examine the attitude of business education students tow...
BACKGROUND OF THE STUDY
The Urban settlement over the world witness great influx of people from the rural area. These pe...
ABSTRACT
The study focuses on assessing the impact of the use of Accounting software in the preparing financial statemen...
ABSTRACT
The study focuses on both quantitative and qualitative analysis of high resolution aeromagnetic data for the estimation of geoth...
ABSTRACT
This study on the impact of promotion of the marketing of a new services with particular note...
ABSTRACT
The main focus of this study is to examine the effect of banditry on rural-urban migration using Kaduna...